Year: 2014 | Month: December | Volume 4 | Issue 3
In silico prediction of buffalo (Bubalus bubalis) pregnancy associated glycoprotein-1 signaling pathway
The present study was conducted to predict and analyze signaling pathway of buffalo pregnancy associated glycoprotein-1 in silico. Various databases viz. String database, Panther pathways, Biocarta pathways were used for deducing signaling of buffalo pregnancy associated glycoprotein-1. Analysis reveals buffalo pregnancy associated glycoprotein-1 exerts their biological function by interacting with cytokines viz. placenta growth factor and SP1 transcription factor. Placental growth factor belongs to the vascular endothelial growth factor superfamily. Vascular endothelial growth factor is mainly involved in cellular proliferation, migration, differentiation, angiogenesis acting through protein kinase-C signaling pathway. SP1 transcription factor is mostly involved in mediators of transcription and signal transduction during cellular process acting through the SMAD factors. In toto pregnancy associated glycoprotein-1 through these factors may exert its biological functions of angiogenesis, endothelial cell growth, proliferation, migration and differentiation enhancing embryonic growth and development. In conclusion from this study the signaling pathway of buffalo pregnancy associated glycoprotein-1 (PAG-1) was predicted in silico.
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