Year: 2021 | Month: December | Volume 11 | Issue 2

Comparing the Clinical Efficacy of Mifepristone and Misoprostol Treatment Protocol for Induction of Parturition in Bitches

Devender Kumar Satish Nain Dinesh Kumar Badsiwal Narendra Singh Archana Choudhary Sanjay Panghal


Successful management of parturition induction is a challenging task in canine. This study made to assess the efficacy of antiprogestagen mifepristone and prostaglandin misoprostol in induction of parturition in bitches. Total of 11 pregnant bitches with gestational age of more than 62 days confirmed by ultrasound scanning and not showing any sings of initiation of parturition were selected. Induction of parturition was initiated by mifepristone (3 mg/ kg b wt PO) twice a day or a combination of mifepristone (3 mg/kg b wt PO) and misoprostol (200 μg for < 20 kg, 400 μg for > 20 kg b wt, i/vg) 12 h after second dose of mifepristone. The combination of both drugs mifepristone and misoprostol was more effective for parturition induction.

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